<p style="text-align: center;">Liu Tongyu ,Yin Hongn ,Yang Tiansong,Sun Zhongren</p><p style="text-align: center;">(1.Heilongjiang university of traditional chinese medicine,harbin 150040,heilongjiang,china. 2.Second affiliated hospital of heilongjiang university of chinese medicine,harbin 150001,heilongjiang,china;3.Frist affiliated hospital of heilongjiang university of chinese medicine,harbin 150001,heilongjiang,china.)</p><p><strong>Abstract</strong>：autophagy is the orchestrated bulk degradation of damaged organells ,misfolded or aggregated proteins.it is an intracellular recycling system that functions during basal conditions in organelle&nbsp; and&nbsp; protein&nbsp; quality&nbsp; control.loss&nbsp; of&nbsp; basal&nbsp; autophagy&nbsp; in&nbsp; the&nbsp; central&nbsp; nervous&nbsp; system&nbsp; is closely related to agerelated neurodegeneration .The effect of acupuncture on many diseases ,as pd,has been verified,as a natural non-toxic side effect therapy.This has important significance for the&nbsp; treatment&nbsp; of&nbsp; neurodegenerative&nbsp; diseases&nbsp; and&nbsp; the&nbsp; mechanism&nbsp; of&nbsp; acupuncture. The&nbsp; effect&nbsp; of acupuncture on neurodegenerative diseases and the regulation of autophagy will be discussed in this article.</p><p><strong>Keyword</strong>:autophagy;acupuncture;neurodegenerative diseases&nbsp;</p><p><br/></p>