<p style="text-align: center;">SHI Renyi , LIANG Yi , Du Junying , Fang Junfan</p><p style="text-align: justify;"><strong>Abstract</strong>:&nbsp; Bone cancer pain mostly due to lung cancer, breast cancer and prostate cancer caused by bone metastases, is a stubborn refractory pain. Now there are relevant research for pathological mechanism&nbsp; of&nbsp; bone&nbsp; cancer&nbsp; pain,&nbsp; but&nbsp; still&nbsp; can&nbsp; not&nbsp; clear&nbsp; its&nbsp; specific&nbsp; mechanism.&nbsp; P2X&nbsp; receptormediated purinergic signals in tumor growth, metastasis-related pathological mechanisms have a very&nbsp; important&nbsp; role,&nbsp; but&nbsp; also&nbsp; involved&nbsp; in&nbsp; the&nbsp; formation&nbsp; and&nbsp; maintenance&nbsp; of&nbsp; cancer&nbsp; pain.&nbsp; P2X receptor is a gated ion channel of adenosine triphosphate (ATP), which mainly includes 7 subtypes of P2X1-P2X7. Preliminary studies have shown that P2X3, P2X4, P2X6 and P2X7 receptors are involved in the development of bone cancer pain, and the related mechanisms exist difference. This review summarizes the mechanisms involved in the involvement of P2X receptors in the development and maintenance of bone cancer pain and further confirms that P2X receptors play a key role in bone cancer pain.</p><p style="text-align: justify;"><strong>Key words</strong>: P2X receptor, bone tumor, pain , mechanism</p><p><br/></p>