Research progress on the mechanism of acupuncture treatment for vascular dementia

针刺治疗血管性痴呆机制研究进展

Wei SUN（孙玮）^a, Ying-hua CHEN（陈英华）^b*, Tong-yan LIU（刘同岩）^a, Xiao-qing SU（苏晓庆）^b, Rui-qi QIN（秦瑞琦）^b

^a Heilongjiang University of Chinese Medicine, Harbin 150040, China (黑龙江中医药大学，哈尔滨150040,中国)

^b Department of Acupuncture, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China（黑龙江中医药大学附属第一医院针灸科，哈尔滨150040，中国）

Abstract

Acupuncture can intervene with and treat vascular dementia (VD) through multiple targets and pathways. The mechanisms of its action involve inhibiting central inflammatory responses, regulating neuronal synaptic plasticity, modulating oxidative stress, reducing neuronal apoptosis, and adjusting cellular autophagy. This paper summarizes researches on the mechanisms of acupuncture treatment for VD over the past decade, aiming to provide theoretical support for the clinical application of acupuncture in treating VD and offer a reference for future in-depth research in this field.

【摘要】

针刺可通过多靶点、多途径对血管性痴呆（VD）进行干预和治疗，其作用机制涉及抑制中枢炎性反应、调控神经元突触可塑性、调节氧化应激、减少神经细胞凋亡、调控细胞自噬等方面。本文对近10年针刺治疗VD相关机制的研究进行总结，以期为针刺治疗VD的临床应用提供理论支持，为今后深入开展相关研究提供参考。