Research progress on the mechanism of acupuncture in the treatment of secondary brain injury after intracerebral hemorrhage

针刺治疗脑出血继发性脑损伤机制的研究进展

Jing-wen TIAN (田静文)^a, Bo SUN (孙波)^b, Xiao-xiao ZHANG (张晓晓)^a, Ying KONG (孔莹)^a,b

^a Graduate School of Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang Province, China (黑龙江中医药大学研究生学院，哈尔滨150040，中国)

^b Department of Acupuncture and Moxibustion, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, Heilongjiang Province, China （黑龙江中医药大学附属第二医院针灸科，哈尔滨150001，中国）

Abstract

Intracerebral hemorrhage is a major cause of death in humans, with high morbidity, mortality, and disability rates. Secondary brain injury after intracerebral hemorrhage is a consequence of brain edema and neurological dysfunction. Acupuncture is markedly effective against secondary brain injury, and various mechanisms are involved in its action, such as inhibition of inflammatory cascades, inhibition of oxidative stress, attenuation of brain edema, inhibition of nerve cell death, and regulation of neural plasticity. This paper summarizes the mechanism underlying the effects of acupuncture on secondary brain injury after intracerebral hemorrhage in recent years to provide new ideas for subsequent research.

【摘要】

脑出血是导致人类死亡的主要原因之一，具有较高的发病率、死亡率和致残率。脑出血后继发性脑损伤是造成脑水肿、神经功能障碍的重要因素。针刺治疗继发性脑损伤效果显著，其作用机制与抑制炎症级联反应、抑制氧化应激、减轻脑水肿、抑制神经细胞死亡、调节神经可塑性等多种途径有关。本文总结近年来针刺治疗脑出血后继发性脑损伤机制的研究进展，以期为后续研究提供新思路。